Neurologic Deficit and Cerebral ATP Depletion after Temporary Focal Ischemia in Cats
نویسندگان
چکیده
منابع مشابه
Transient Focal Cerebral Ischemia in Cats
Background and Purpose: TA3090 (Clentiazem) has been shown to have cerebrovascular protective properties in three experimental studies. An in vivo investigation was undertaken to determine its effects on pial arteries and cerebral blood flow and its therapeutic value in transient focal cerebral ischemia. Methods: This experiment was divided into two protocols. In the first, 200 or 400 ug/kg per...
متن کاملNeurological deficit and cerebral infarction after temporary middle cerebral artery occlusion in unanesthetized cats.
Forty-four unanesthetized cats underwent temporary middle cerebral artery (MCA) occlusion with an implanted, externally controlled balloon cuff occluder. The occlusion was reversed to allow reperfusion of the MCA after 2 min to 24 hr of ischemia. Fourteen cats had temporary occlusions lasting 2 min to 3 hr; their neurological deficits improved or resolved after reperfusion, and brain sections s...
متن کاملFunctional evaluation of temporary focal cerebral ischemia: experimental model.
OBJECTIVE Despite cerebral ischemia being a frequent clinical pathologic state, the tolerance of neural tissue to oxygen absence and to reperfusion is controversial. This study aims to evaluate the effects of focal cerebral ischemia/reperfusion, by analyzing the mitochondrial respiration. METHOD Sixty-four adult rats underwent focal cerebral ischemia by middle cerebral artery occlusion, durin...
متن کاملEffect of GM1 ganglioside after focal cerebral ischemia in halothane-anesthetized cats.
The effect of the ganglioside GM1 was studied in a focal cerebral ischemia model in 30 cats consisting of 2 hours of middle cerebral artery occlusion followed by 4 hours of recirculation. The cerebrocortical electrical activity, extracellular potassium activity, and microcirculation indicated by NAD/NADH fluorescence were measured during occlusion as well as during recirculation in the core of ...
متن کاملL-NAME and 7-Nitroindazole Reduces Brain Injuries in Transient Focal Cerebral Ischemia in Rat
Background: The role of nitric oxide (NO) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all. Objective: To investigate the role of NO of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, L-NAME, a non selective NO synthase inhibitor...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1984
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1984.25